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From the US National Institutes of Health- Research Papers

The effect of povidone-iodine on thyroid function of neonates with different birth sizes

Jeng MJ, Lin CY, Soong WJ, Hsiao KJ, Hwang B, Chiang SH.
Department of Pediatrics, Veterans General Hospital-Taipei, Taiwan.

The aim of this study was to elucidate the role of povidone-iodine (PV-I) on thyroid function of newborns with different birth sizes in a high iodine-intake city.

Serial measurements of serum thyroxine (T4) and thyrotropin (TSH) levels were done in 44 newborns locally treated with 10% PV-I for insertion of percutaneous central venous catheters.

The results showed that the thyroid function was influenced prominently in very-low-birth weight (VLBW) babies.

TSH went significantly higher after application of PV-I for 48 hours in VLBW babies.

The smaller the babies were, the lower the T4 at birth and thereafter.

In conclusion, PV-I is suggested to be avoided for single application on a wide skin surface in VLBW babies, even in an area with high iodine-intake population.

PMID: 9926509 [PubMed - indexed for MEDLINE]