Gentamicin Ophthalmic (Genoptic, Garamycin)

Gentamicin and Prednisolone ophthalmic (Pred-G, Pred-G S.O.P.)

Category:

• Antibiotic

Description:

• Aminoglycoside antibiotic

• Aminoglycoside and steroidal anti-inflammatory combination

Indications:

• Ocular infections due to susceptible organisms (see Gentamicin injection monograph)

Contraindications:

• Generally not indicated for long-term therapy due to nephrotoxocity and ototoxicity

Precautions:

• Pregnancy category D

• Use proper ophthalmic application procedures (tilt head backward, pull lower eyelid downward to make a “cup”, avoid touching tip of bottle, drop in eye, place light pressure on lacrimal sac for ~1 minute)

• Ophthalmic suspension must be shaken prior to use

• Notify provider immediately at the first sign of skin rash or other allergic reaction  

• Use of steroids in the presence of viral infections such as herpes, may prolong or worsen the severity of the viral infection.

Adverse Reactions (Side Effects):

• Transient irritation, burning or stinging

• May cause white crystalline precipitates and lid margin crusting

Dosage:

• Administered by ophthalmic drops and ointment

• Gentamicin Ophthalmic Drops:

  • 1-2 drops into affected eye(s) every 4 hours

• Gentamicin Ophthalmic Ointment:

  • Apply 1/2 inch ribbon of ointment into the affected conjunctival sac(s) every 4 hours.