Ketoconazole Cream 2% (Nizoral)

Category:

• Antifungal

  Description:

• Antifungal

  Indications:

• Systemic Candidiasis

• Mucocutaneous Candidiasis

• Oral Candidiasis (thrush)

• Tinea corporis, tinea cruris, tinea versicolor

• Severe recalcitrant cutaneous dermatophytic infections non-responsive to griseofulvin or other antifungals

  Contraindications:

• Not used for fungal menigitis

Precautions:

• Pregnancy category C

• Requires acidic pH for absorption, therefore do not take with antacids.

• Take with food to increase absorption and decrease GI adverse effects.

• Notify healthcare provider is patient experiences anorexia, fatigue, jaundice, darkened urine or pale stools, due to possible liver dysfunction.

• Concomitant use with alcohol may lead to a disulfiram-like reaction.

  Adverse Reactions (Side Effects):

• Nausea and vomiting (3-10%)

• Severe irritation with topical application

Dosage:

Administered as an oral tablet, suspension or topical cream

Adult

• 200-400mg once a day

Children (> 2 years old):

• 3.3-6.6 mg/kg/day as a single daily dose

Topical:

• Apply once or twice a day to affected area and immediate surrounding areas for 14 days.