Spectinomycin (Trobicin)

Category:

• Antibiotic

Description:

• Miscellaneous antibiotic

Indications:

• Gonorrhea due N. gonorrhoeae

Contraindications:

• None

Precautions:

• Pregnancy category B

• Not effective against syphilis

• Use spectinomycin only in patients intolerant to cephalosporins or quinolones

Adverse Reactions (Side Effects):

• Single dose reactions: 

  • sore injection site

  • urticaria

  • dizziness

  • nausea

  • chills

  • fever

  • insomnia

• Multiple-dose reactions: 

  • decreased hemoglobin, hematocrit and creatinine clearance

  • elevations of alkaline phosphatase, BUN and ALT  

Dosage:

• Administered orally IM injection ONLY deep in upper outer quadrant of gluteal muscle

• Uncomplicated gonococcal infections: 

  • 2 grams IM

• Gonococcal infections in pregnancy: 

  • single 2 gram IM dose

• Disseminated gonococcal infections: 

  • 2 grams q12h

• Geographic areas having antibiotic resistance: 

  • 4 grams IM total (2 grams per each side)